This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Analysis of cellular mechanotransduction, the mechanism by which cells convert mechanical
signals into biochemical responses, has focused on identification of critical …

Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Forces are increasingly recognized as major regulators of cell structure and function, and
the mechanical properties of cells are essential to the mechanisms by which cells sense …

The intraflagellar transport (IFT) proteins Ift172/Wimple and Polaris/Ift88 and the anterograde
IFT motor kinesin-II are required for the production and maintenance of cilia. These proteins …

Primary cilia are sensory organelles that translate extracellular chemical and mechanical
cues into cellular responses. Bone is an exquisitely mechanosensitive organ, and its …

Polycystic kidney disease (PKD) is a common human genetic illness. It is characterized by
the formation of multiple kidney cysts that are thought to result from over-proliferation of …

Proteins associated with autosomal dominant and autosomal recessive polycystic kidney
disease (polycystin-1, polycystin-2, and fibrocystin) localize to various subcellular …

The transient receptor potential (TRP) superfamily comprises a group of non-selective cation
channels that sense and respond to changes in their local environments. TRP channels are …

Cilia are microtubule-based organelles that project like antennae from the surface of most
cells in the body. Motile cilia move fluid past cells, for example mucus in the airway. Non …