Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models
The rapid scale-up of research on coronavirus disease 2019 (COVID-19) has spawned a
large number of potential vaccines and immunotherapies, accompanied by a …
large number of potential vaccines and immunotherapies, accompanied by a …
The status of tuberculosis vaccine development
LK Schrager, J Vekemens, N Drager… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis represents the leading global cause of death from an infectious agent.
Controlling the tuberculosis epidemic thus represents an urgent global public health priority …
Controlling the tuberculosis epidemic thus represents an urgent global public health priority …
Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine
SG Hansen, DE Zak, G Xu, JC Ford, EE Marshall… - Nature medicine, 2018 - nature.com
Despite widespread use of the bacille Calmette–Guérin (BCG) vaccine, tuberculosis (TB)
remains a leading cause of global mortality from a single infectious agent (Mycobacterium …
remains a leading cause of global mortality from a single infectious agent (Mycobacterium …
Lymph nodes—The neglected battlefield in tuberculosis
Lymph nodes, particularly thoracic lymph nodes, are among the most common sites of
extrapulmonary tuberculosis (TB). However, Mycobacterium tuberculosis (Mtb) infection in …
extrapulmonary tuberculosis (TB). However, Mycobacterium tuberculosis (Mtb) infection in …
[HTML][HTML] Ultra-low dose aerosol infection of mice with Mycobacterium tuberculosis more closely models human tuberculosis
Tuberculosis (TB) is a heterogeneous disease manifesting in a subset of individuals infected
with aerosolized Mycobacterium tuberculosis (Mtb). Unlike human TB, murine infection …
with aerosolized Mycobacterium tuberculosis (Mtb). Unlike human TB, murine infection …
Rhesus macaques are more susceptible to progressive tuberculosis than cynomolgus macaques: a quantitative comparison
P Maiello, RM DiFazio, AM Cadena… - Infection and …, 2018 - Am Soc Microbiol
In the past 2 decades, it has become increasingly clear that nonhuman primates, specifically
macaques, are useful models for human tuberculosis (TB). Several macaque species have …
macaques, are useful models for human tuberculosis (TB). Several macaque species have …
Animal models of tuberculosis: Lesson learnt
AK Singh, UD Gupta - Indian Journal of Medical Research, 2018 - journals.lww.com
Tuberculosis (TB) remains a leading cause of death globally among infectious diseases that
has killed more numbers of people than any other infectious diseases. Animal models have …
has killed more numbers of people than any other infectious diseases. Animal models have …
Chronic immune activation in TB/HIV co-infection
HIV co-infection is the most critical risk factor for the reactivation of latent tuberculosis (TB)
infection (LTBI). While CD4+ T cell depletion has been considered the major cause of HIV …
infection (LTBI). While CD4+ T cell depletion has been considered the major cause of HIV …
MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in …
AD White, L Sibley, C Sarfas, A Morrison, J Gullick… - npj Vaccines, 2021 - nature.com
A single intradermal vaccination with MTBVAC given to adult rhesus macaques was well
tolerated and conferred a significant improvement in outcome following aerosol exposure to …
tolerated and conferred a significant improvement in outcome following aerosol exposure to …
Why don't we have an effective tuberculosis vaccine yet?
Mycobacterium tuberculosis (M. tb) has co-evolved with humans for thousands of years, to
cause tuberculosis (TB). The success of M. tb as a pathogen is in part because of the ways …
cause tuberculosis (TB). The success of M. tb as a pathogen is in part because of the ways …