Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly
possess a novel helix-turn-helix DNA-binding motif. Following the initial identification of two …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

Type I and II interferons (IFNs) stimulate pro-inflammatory programs that are critical for
immune activation, but also induce immune-suppressive feedback circuits that impede …

Members of the interferon-regulatory factor (IRF) proteins family were originally identified as
transcriptional regulators of the Type I interferon system. Thanks to consistent advances …

Interferons are a large family of multifunctional secreted proteins involved in antiviral
defense, cell growth regulation and immune activation. Viral infection induces transcription …

Nine interferon regulatory factors (IRFs) compose a family of transcription factors in
mammals. Although this family was originally identified in the context of the type I interferon …

Toll-like receptor 3 (TLR3) belongs to a family of evolutionary conserved innate immune
recognition molecules and recognizes double-stranded RNA, a molecular pattern …

Polarization of CD4+ T helper cells toward either a Th1 or Th2 response can significantly
influence host immunity to pathogens. IL-4 and IFN-γ are the signature cytokines of Th2 and …

A family of transcription factors, the interferon regulatory factors (IRF), was identified
originally in the context of the regulation of the type I interferon (IFN)‐α/β system. The IRF …

Interferon (IFN) regulatory factor (IRF)-2 was originally described as an antagonist of IRF-1–
mediated transcriptional regulation of IFN-inducible genes. IRF-1−/− mice exhibit defective T …