Treatment strategies for cryptococcal infection: challenges, advances and future outlook

KR Iyer, NM Revie, C Fu, N Robbins… - Nature Reviews …, 2021 - nature.com
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

Candidiasis: From cutaneous to systemic, new perspectives of potential targets and therapeutic strategies

H Lu, T Hong, Y Jiang, M Whiteway, S Zhang - Advanced Drug Delivery …, 2023 - Elsevier
Candidiasis is an infection caused by fungi from a Candida species, most commonly
Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on …

Creating and screening natural product libraries

BAP Wilson, CC Thornburg, CJ Henrich… - Natural product …, 2020 - pubs.rsc.org
Covering: up to 2020 The National Cancer Institute of the United States (NCI) has initiated a
Cancer Moonshot program entitled the NCI Program for Natural Product Discovery. As part …

New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics

J Geddes‐McAlister, RS Shapiro - … of the New York Academy of …, 2019 - Wiley Online Library
Fungal pathogens are a growing threat to public health. As human immunodeficiency
becomes increasingly common, fungal infections are becoming more prevalent. The use of …

AIEgen-based smart system for fungal-infected wound monitoring and on-demand photodynamic therapy

K Zhou, S Wang, L Xu, H Li, Y Wang, Z Qiu, G Zhang… - Matter, 2023 - cell.com
Smart portable systems with integrated diagnosis and treatment play an important role in
modern life. Real-time evaluation of wound infection and providing on-demand therapies …

Utilizing cross-species co-cultures for discovery of novel natural products

L Zhuang, H Zhang - Current Opinion in Biotechnology, 2021 - Elsevier
Highlights•Cross-species co-cultures can be used to activate cryptic genes' expression for
biosynthesis of novel natural products.•A variety of co-cultivation methods have been …

Update on fungal lipid biosynthesis inhibitors as antifungal agents

M Vishwakarma, T Haider, V Soni - Microbiological Research, 2024 - Elsevier
Fungal diseases today represent a world-wide problem. Poor hygiene and decreased
immunity are the main reasons behind the manifestation of this disease. After COVID-19, an …

The Potential use of fungal co-culture strategy for discovery of new secondary metabolites

S Xu, M Li, Z Hu, Y Shao, J Ying, H Zhang - Microorganisms, 2023 - mdpi.com
Fungi are an important and prolific source of secondary metabolites (SMs) with diverse
chemical structures and a wide array of biological properties. In the past two decades …

Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters

SS El-Hawary, MHA Hassan, AO Hudhud… - RSC …, 2023 - pubs.rsc.org
This review summarizes the recent advances in the elicitation approaches used to activate
the actinomycete genome's cryptic secondary metabolite gene clusters and shows the …

Searching for new antifungals for the treatment of cryptococcosis

NSO Sousa, JDR Almeida, H Frickmann… - Revista da Sociedade …, 2023 - SciELO Brasil
There is a consensus that the antifungal repertoire for the treatment of cryptococcal
infections is limited. Standard treatment involves the administration of an antifungal drug …