Kisspeptins and reproduction: physiological roles and regulatory mechanisms

L Pinilla, E Aguilar, C Dieguez, RP Millar… - Physiological …, 2012 - journals.physiology.org
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour

EG Mills, C Izzi-Engbeaya, A Abbara… - Nature Reviews …, 2021 - nature.com
The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and
their pathophysiological roles are increasingly the subject of investigation. Evidence …

Effects of psychological stress on male fertility

VH Nargund - Nature Reviews Urology, 2015 - nature.com
Psychological stress can be defined as any uncomfortable'emotional experience'
accompanied by predictable biochemical, physiological and behavioural changes or …

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

SN Mann, N Hadad, M Nelson Holte, AR Rothman… - Elife, 2020 - elifesciences.org
Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated
by obesity. Dietary interventions can reverse metabolic declines and slow aging, although …

Current perspectives on kisspeptins role in behaviour

EG Mills, L Yang, A Abbara, WS Dhillo… - Frontiers in …, 2022 - frontiersin.org
The neuropeptide kisspeptin is now well-established as the master regulator of the
mammalian reproductive axis. Beyond the hypothalamus, kisspeptin and its cognate …

Neuropeptides as regulators of the hypothalamus-pituitary-gonadal (HPG) axis activity and their putative roles in stress-induced fertility disorders

M Gołyszny, E Obuchowicz, M Zieliński - Neuropeptides, 2022 - Elsevier
Neuropeptides being regulators of the hypothalamus-pituitary-adrenal (HPA) axis activity,
also affect the function of the hypothalamus-pituitary-gonadal (HPG) axis by regulating …

Kisspeptin-8 induces anxiety-like behavior and hypolocomotion by activating the HPA axis and increasing GABA release in the nucleus accumbens in rats

KE Ibos, É Bodnár, Z Bagosi, Z Bozsó, G Tóth, G Szabó… - Biomedicines, 2021 - mdpi.com
Kisspeptins (Kp) are RF-amide neuropeptide regulators of the reproductive axis that also
influence anxiety, locomotion, and metabolism. We aimed to investigate the effects of …

Emerging roles of kisspeptin in sexual and emotional brain processing

AN Comninos, WS Dhillo - Neuroendocrinology, 2018 - karger.com
The emergence of kisspeptin as a crucial regulator of the hypothalamo-pituitary-gonadal
(HPG) axis over the last 14 years has answered many questions as to the control of …

Effects of kisspeptin-13 on the hypothalamic-pituitary-adrenal axis, thermoregulation, anxiety and locomotor activity in rats

K Csabafi, M Jászberényi, Z Bagosi, N Lipták… - Behavioural brain …, 2013 - Elsevier
Kisspeptin is a mammalian amidated neurohormone, which belongs to the RF-amide
peptide family and is known for its key role in reproduction. However, in contrast with the …

Kisspeptin and the control of emotions, mood and reproductive behaviour

EGA Mills, WS Dhillo… - Journal of …, 2018 - joe.bioscientifica.com
Reproduction is fundamental for the survival of all species and requires meticulous
synchronisation of a diverse complement of neural, endocrine and related behaviours. The …