APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
R Fernández-Calle, SC Konings… - Molecular …, 2022 - Springer
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches
The APOE ε4 allele remains the strongest genetic risk factor for sporadic Alzheimer's
disease and the APOE ε2 allele the strongest genetic protective factor after multiple large …
disease and the APOE ε2 allele the strongest genetic protective factor after multiple large …
Multifaceted roles of APOE in Alzheimer disease
RJ Jackson, BT Hyman, A Serrano-Pozo - Nature Reviews Neurology, 2024 - nature.com
For the past three decades, apolipoprotein E (APOE) has been known as the single greatest
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …
Long-term prognosis and educational determinants of brain network decline in older adult individuals
Older adults with lower education are at greater risk for dementia. It is unclear which brain
changes lead to these outcomes. Longitudinal imaging-based measures of brain structure …
changes lead to these outcomes. Longitudinal imaging-based measures of brain structure …
Sex mediates relationships between regional tau pathology and cognitive decline
Objective The goal of this study was to examine sex differences in tau distribution across the
brain of older adults, using positron emission tomography (PET), and investigate how these …
brain of older adults, using positron emission tomography (PET), and investigate how these …
Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease
Background To assess the effects of apolipoprotein E (ApoE) ε4 genotype on amyloid-β (Aβ)
and tau burden and their longitudinal changes in Alzheimer's disease (AD) spectrum …
and tau burden and their longitudinal changes in Alzheimer's disease (AD) spectrum …
The central role of tau in Alzheimer's disease: From neurofibrillary tangle maturation to the induction of cell death
DR Thal, SO Tomé - Brain Research Bulletin, 2022 - Elsevier
The tau protein (τ) is one of the two hallmark proteins of Alzheimer's disease (AD) together
with the amyloid β protein (Aβ). In contrast to Aβ, abnormally phosphorylated τ (p-τ) can also …
with the amyloid β protein (Aβ). In contrast to Aβ, abnormally phosphorylated τ (p-τ) can also …
Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET
Objective To assess whether Alzheimer disease (AD) clinical presentation and APOE4
relate to the burden and topography of β-amyloid (Aβ) and tau pathologies using in vivo PET …
relate to the burden and topography of β-amyloid (Aβ) and tau pathologies using in vivo PET …
Assessment of demographic, genetic, and imaging variables associated with brain resilience and cognitive resilience to pathological tau in patients with Alzheimer …
R Ossenkoppele, CH Lyoo, J Jester-Broms… - JAMA …, 2020 - jamanetwork.com
Importance Better understanding is needed of the degree to which individuals tolerate
Alzheimer disease (AD)–like pathological tau with respect to brain structure (brain …
Alzheimer disease (AD)–like pathological tau with respect to brain structure (brain …
Clinical validity of increased cortical uptake of [18F]flortaucipir on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase biomarker …
Abstract Purpose In 2017, the Geneva Alzheimer's disease (AD) Biomarker Roadmap
initiative adapted the framework of the systematic validation of oncological diagnostic …
initiative adapted the framework of the systematic validation of oncological diagnostic …