The misfolding and aggregation of α-synuclein is the general hallmark of a group of
devastating neurodegenerative pathologies referred to as synucleinopathies, such as …

Advanced age is an important risk factor for the worse clinical presentation of gliomas,
especially glioblastoma (GBM). The tumor microenvironment (TME) in elderly GBM (eGBM) …

Patients with Parkinson's disease and cognitive impairment (PD-CI) deteriorate faster than
those without cognitive impairment (PD-NCI), suggesting an underlying difference in the …

Background The brain aging in the general population and patients with neurological
disorders is not well understood. Purpose To characterize brain aging in the above …

The brain-age gap, ie the difference between the brain age estimated from structural MRI
data and the chronological age of an individual, has been proposed as a summary measure …

Accelerated brain aging (ABA) intricately links with age-associated neurodegenerative and
neuropsychiatric diseases, emphasizing the critical need for a nuanced exploration of …

The intricate dynamics of brain aging, especially the neurodegenerative mechanisms driving
accelerated (ABA) and resilient brain aging (RBA), are pivotal in neuroscience …

Rationale and Objectives Although both Multiple system atrophy (MSA) and Parkinson's
disease (PD) belong to alpha-synucleinopathy, they have divergent clinical courses and …

Molecular neuroimaging techniques, like PET and SPECT, offer invaluable insights into the
brain's in-vivo biology and its dysfunction in neuropsychiatric patients. However, the …

T1-weighted imaging holds wide applications in clinical and research settings; however, the
challenge of inter-scanner variability arises when combining data across scanners, which …