Matrix metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: recent advances
H Huang - Sensors, 2018 - mdpi.com
As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a
significant protease which plays vital roles in many biological processes. MMP-9 can cleave …
significant protease which plays vital roles in many biological processes. MMP-9 can cleave …
Angiogenesis after ischemic stroke
J Fang, Z Wang, C Miao - Acta Pharmacologica Sinica, 2023 - nature.com
Owing to its high disability and mortality rates, stroke has been the second leading cause of
death worldwide. Since the pathological mechanisms of stroke are not fully understood …
death worldwide. Since the pathological mechanisms of stroke are not fully understood …
Novel matrix metalloproteinase-9 (MMP-9) inhibitors in cancer treatment
ZA Rashid, SK Bardaweel - International journal of molecular sciences, 2023 - mdpi.com
Matrix metalloproteinases (MMPs) belong to a family of zinc-dependent proteolytic
metalloenzymes. MMP-9, a member of the gelatinase B family, is characterized as one of the …
metalloenzymes. MMP-9, a member of the gelatinase B family, is characterized as one of the …
Tridimensional cell culture of dermal fibroblasts promotes exosome-mediated secretion of extracellular matrix proteins
Extracellular matrix (ECM) secretion, deposition and assembly are part of a whole complex
biological process influencing the microenvironment and other cellular behaviors. Emerging …
biological process influencing the microenvironment and other cellular behaviors. Emerging …
Genetic deletion or pharmacological inhibition of cyclooxygenase-2 reduces blood-brain barrier damage in experimental ischemic stroke
Cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 are two crucial mediators
contributing to blood-brain barrier (BBB) damage during cerebral ischemia. However, it is …
contributing to blood-brain barrier (BBB) damage during cerebral ischemia. However, it is …
Ulinastatin protects brain against cerebral ischemia/reperfusion injury through inhibiting MMP-9 and alleviating loss of ZO-1 and occludin proteins in mice
XF Li, XJ Zhang, C Zhang, LN Wang, YR Li… - Experimental …, 2018 - Elsevier
Abstract Background The effects of Ulinastatin (UTI) on the blood-brain barrier (BBB) in the
acute phase of cerebral ischemia/reperfusion (I/R) are not clear. This study was to …
acute phase of cerebral ischemia/reperfusion (I/R) are not clear. This study was to …
MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K/AKT pathway
K Tian, G Du, X Wang, X Wu, L Li, W Liu… - Molecular Biology Reports, 2022 - Springer
Background Wilms' tumour (WT) is a malignant tumour of childhood with the typical
symptoms of an abdominal mass. Tumour-associated macrophages (TAMs) accumulate and …
symptoms of an abdominal mass. Tumour-associated macrophages (TAMs) accumulate and …
In vitro model of the blood-brain barrier established by co-culture of primary cerebral microvascular endothelial and astrocyte cells
Y Wang, N Wang, B Cai, G Wang, J Li… - Neural regeneration …, 2015 - journals.lww.com
Drugs for the treatment and prevention of nervous system diseases must permeate the blood-
brain barrier to take effect. In vitro models of the blood-brain barrier are therefore important …
brain barrier to take effect. In vitro models of the blood-brain barrier are therefore important …
Vascular basement membrane alterations and β-amyloid accumulations in an animal model of cerebral small vessel disease
F Held, AWJ Morris, D Pirici, S Niklass… - Clinical …, 2017 - portlandpress.com
Non-amyloid cerebral small vessel disease (CSVD) and cerebral amyloid angiopathy (CAA)
may be interrelated through the damaged basement membranes (BMs) and extracellular …
may be interrelated through the damaged basement membranes (BMs) and extracellular …
[HTML][HTML] Computational study of effective matrix metalloproteinase 9 (MMP9) targeting natural inhibitors
N Liu, X Wang, H Wu, X Lv, H Xie, Z Guo… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Object: The present study screened ideal lead natural compounds that could target and
inhibit matrix metalloproteinase 9 (MMP9) protein from the ZINC database to develop drugs …
inhibit matrix metalloproteinase 9 (MMP9) protein from the ZINC database to develop drugs …