Drug conjugates are chemotherapeutic or cytotoxic agents covalently linked to targeting
ligands such as an antibody or a peptide via a linker. While antibody–drug conjugates …

The discovery of RNA interference, first in plants and Caenorhabditis elegans and later in
mammalian cells, led to the emergence of a transformative view in biomedical research …

Although cancer cells are not generally controlled by normal regulatory mechanisms, tumor
growth is highly dependent on the supply of oxygen, nutrients, and host-derived regulators. It …

Importance of the field: High mortality rates with cancers warrant further development of
earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin …

The Eph receptor tyrosine kinases and ephrin ligands have been studied extensively for
their roles in developmental processes. In recent years, Eph receptors and ephrins have …

Tumors have been recently recognized as aberrant organs composed of a complex mixture
of highly interactive cells that in addition to the cancer cell include stroma (fibroblasts …

Context.—Metastatic disease is the most critical determinant of resectability of pancreatic
cancer and accounts for the poor outcome of patients with this disease. Thus, a better …

Photothermal ablation (PTA) is an emerging technique that uses near-infrared (NIR) laser
light–generated heat to destroy tumor cells. However, complete tumor eradication by PTA …

The large families of Eph receptor tyrosine kinases and their ephrin ligands transduce
signals in a cell-cell contact-dependent fashion and thereby coordinate the growth …

Receptor tyrosine kinases of the Eph family are up-regulated in different types of cancer.
EphB4 and its ligand ephrin-B2 have been linked to breast cancer, but little is known about …