Sustainable biomass hydrodeoxygenation in biphasic systems

H Wei, Z Wang, H Li - Green Chemistry, 2022 - pubs.rsc.org
Biomass and its derivatives require upgrades to produce high-quality liquid fuels and bulk
chemicals by reducing their oxygen functionalities comparable to petroleum resources …

Highly polymorphous nicotinamide and isonicotinamide: solution versus melt crystallization

N Fellah, CJ Zhang, C Chen, CT Hu, B Kahr… - Crystal Growth & …, 2021 - ACS Publications
The crystallization of nicotinamide (NA) and its constitutional isomer, isonicotinamide (INA),
is compared. NA formed eight polymorphs from the melt and two from solution, whereas INA …

Bioavailability-Enhancing Cocrystals: Screening, In Vivo Predictive Dissolution, and Supersaturation Maintenance

D Chen, W Huang, Q Zhang, Z Zhang… - Crystal Growth & …, 2022 - ACS Publications
Cocrystal engineering for bioavailability enhancement is still a serendipitous process, which
requires systematic solution crystallization, in vivo predictive dissolution, and …

Solvent Effect on Molecular Conformational Evolution and Polymorphic Manipulation of Cimetidine

B Tian, H Hao, X Huang, T Wang, J Wang… - Crystal Growth & …, 2023 - ACS Publications
In the field of pharmaceutical crystallization, the success of polymorphic manipulation is vital
to the performance of pharmaceutical formulations, and the choice of solvents might affect …

Selective nucleation of polymorphs induced by multiple conformations and self-association

C Liu, Y Wang, Y Zhao, X Li, N Wang… - Crystal Growth & …, 2022 - ACS Publications
In an attempt to understand the relationship between solution chemistry and polymorphic
nucleation, the flexible molecule chlorpropamide is used as a model compound to study its …

Updated Abraham model correlations for describing solute transfer into both 2-Pentanol and 3-Methyl-1-butanol based on much larger data sets

T Kandi, R Motati, S Motati, N Shanmugam… - … and Chemistry of …, 2023 - Taylor & Francis
Mole fraction solubilities of 4-tert-butylbenzoic acid, 3-chlorobenzoic acid, 2-methyl-3-
nitrobenzoic acid, 3-methyl-4-nitrobenzoic acid, 3, 4, 5-trimethoxybenzoic acid, isophthalic …

Salts and polymorph screens for bedaquiline

M Okezue, S Bogdanowich-Knipp, D Smith, M Zeller… - AAPS …, 2021 - Springer
Bedaquiline is used to treat multi-resistant tuberculosis in adults. The fumarate salt is
commercially available and used in the product Sirturo. To provide open access to …

Features of the conformation of galunisertib molecules in the crystal structures of its solvates

VN Serezhkin, AV Savchenkov - CrystEngComm, 2021 - pubs.rsc.org
Crystal chemical analysis of 11 solvates of galunisertib (GAL· Q where GAL is C22H19N5O,
Q is a solvent molecule)–one of the most prolific compounds in the number of structurally …

Designing safer solvents to replace methylene chloride for liquid chromatography applications using thin-layer chromatography as a screening tool

A Sharma, E Yu, G Morose, DT Nguyen, WT Chen - Separations, 2021 - mdpi.com
Methylene chloride, commonly known as dichloromethane (DCM), is a widely used chemical
for chromatography separation within the polymer, chemical, and pharmaceutical industries …

Co-crystals of zwitterionic GABA API's pregabalin and phenibut: properties and application

D Komisarek, THH Sohi, V Vasylyeva - CrystEngComm, 2022 - pubs.rsc.org
We present several multicomponent crystalline species formed by zwitterionic GABA
analogues pregabalin and phenibut. These compounds are evaluated based on their crystal …