Polyphenols are found ubiquitously in plants and their regular consumption has been
associated with a reduced risk of a number of chronic diseases, including cancer …

PCSK9 is an established target for cholesterol-lowering therapies. Further study of PCSK9
regulatory mechanisms may identify additional control points for pharmacological inhibition …

Cholesterol is an essential structural component in the cell membranes of most vertebrates.
The biophysical properties of cholesterol and the enzymology of cholesterol metabolism …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in
Western countries and is considered the hepatic manifestation of metabolic syndrome. The …

Phosphatidylcholine (PC) is the major phospholipid component of all plasma lipoprotein
classes. PC is the only phospholipid which is currently known to be required for lipoprotein …

PCSK9 encodes proprotein convertase subtilisin/kexin type 9a (PCSK9), a member of the
proteinase K subfamily of subtilases. Missense mutations in PCSK9 cause an autosomal …

The discovery of autosomal dominant hypercholesterolemic patients with mutations in the
PCSK9 gene, encoding the proprotein convertase NARC-1, resulting in the missense …

Ectopic lipid accumulation has been observed in fish fed a high-lipid diet. However, no
information is available on the mechanism by which dietary lipid levels comprehensively …

Patients with Tangier disease exhibit extremely low plasma HDL concentrations resulting
from mutations in the ATP-binding cassette, sub-family A, member 1 (ABCA1) protein …

Apolipoprotein B100 (apoB100) is expressed primarily in mammalian liver. It has 4536
amino acids, 25 cysteines (16 of which are in intramolecular disulfide bonds), and 20 N …