Chimeric antigen receptor T-cells: an overview of concepts, applications, limitations, and proposed solutions

A Alnefaie, S Albogami, Y Asiri, T Ahmad… - … in bioengineering and …, 2022 - frontiersin.org
Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …

Cancer stemness meets immunity: from mechanism to therapy

P Chen, WH Hsu, J Han, Y Xia, RA DePinho - Cell reports, 2021 - cell.com
Cancer stem cells (CSCs) are self-renewing cells that facilitate tumor initiation, promote
metastasis, and enhance cancer therapy resistance. Transcriptomic analyses across many …

[HTML][HTML] CAR T cell-based immunotherapy for the treatment of glioblastoma

L Maggs, G Cattaneo, AE Dal… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumor in adults. Current treatment options typically consist of surgery followed by …

The glioma immune landscape: A double-edged sword for treatment regimens

S Mahajan, MHH Schmidt, U Schumann - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma (GBM) is the most severe and aggressive form of primary
brain tumor with a poor prognosis. Currently, the treatment for GBM treatment involves …

Highly Sensitive EGFRvIII Detection in Circulating Extracellular Vesicle RNA of Glioma Patients

SM Batool, K Muralidharan, T Hsia, S Falotico… - Clinical Cancer …, 2022 - AACR
Purpose: Liquid biopsy offers an attractive platform for noninvasive tumor diagnosis,
prognostication, and prediction of glioblastoma clinical outcomes. Prior studies report that …

[HTML][HTML] Adult type diffuse gliomas in the new 2021 WHO Classification

M Antonelli, PL Poliani - Pathologica, 2022 - ncbi.nlm.nih.gov
Adult-type diffuse gliomas represent a group of highly infiltrative central nervous system
tumors with a prognosis that significantly varies depending on the specific subtype and …

A novel EGFRvIII T-cell bispecific antibody for the treatment of glioblastoma

R Iurlaro, I Waldhauer, E Planas-Rigol… - Molecular Cancer …, 2022 - AACR
T-cell bispecific antibodies (TCB) are engineered molecules that bind both the T-cell
receptor and tumor-specific antigens. Epidermal growth factor receptor variant III (EGFRvIII) …

EGF receptor modulates HEV entry in human hepatocytes

JA Schrader, TL Burkard, Y Brüggemann, A Gömer… - Hepatology, 2023 - journals.lww.com
EGF receptor modulates HEV entry in human hepatocytes : Hepatology EGF receptor modulates
HEV entry in human hepatocytes : Hepatology AASLD Publications Hepatology Liver …

Neurotransmitters: potential targets in Glioblastoma

Q Huang, L Chen, J Liang, Q Huang, H Sun - Cancers, 2022 - mdpi.com
Simple Summary Aiming to discover potential treatments for GBM, this review connects
emerging research on the roles of neurotransmitters in the normal neural and the GBM …

Targeted EGFR nanotherapy in non-small cell lung cancer

A Crintea, AM Constantin, AC Motofelea… - Journal of Functional …, 2023 - mdpi.com
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality
worldwide. Despite advances in treatment, the prognosis remains poor, highlighting the …