The angiotensin AT2 receptor: from a binding site to a novel therapeutic target

UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - Elsevier
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

Menopause and Parkinson's disease. Interaction between estrogens and brain renin-angiotensin system in dopaminergic degeneration

JL Labandeira-Garcia, AI Rodriguez-Perez… - Frontiers in …, 2016 - Elsevier
The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease (PD)
have not yet been clarified, and it is controversial whether there is a critical period for …

Dopaminergic neuroprotection of hormonal replacement therapy in young and aged menopausal rats: role of the brain angiotensin system

AI Rodriguez-Perez, R Valenzuela, B Villar-Cheda… - Brain, 2012 - academic.oup.com
There is a lack of consensus about the effects of the type of menopause (surgical or natural)
and of oestrogen replacement therapy on Parkinson's disease. The effects of the timing of …

Estrogen elicits dorsal root ganglion axon sprouting via a renin-angiotensin system

A Chakrabarty, A Blacklock, S Svojanovsky… - …, 2008 - academic.oup.com
Many painful conditions occur more frequently in women, and estrogen is a predisposing
factor. Estrogen may contribute to some pain syndromes by enhancing axon outgrowth by …

Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats

M Macova, I Armando, J Zhou, G Baiardi… - …, 2008 - karger.com
We studied the effect of ovariectomy and estrogen replacement on expression of adrenal
angiotensin II AT 1 and AT 2 receptors, aldosterone content, catecholamine synthesis, and …

17β-estradiol modulation of angiotensin II-stimulated response in cardiac fibroblasts

JA Stewart Jr, DO Cashatt, AC Borck, JE Brown… - Journal of molecular and …, 2006 - Elsevier
The ovarian hormone, 17β-estradiol, has been suggested to play an important role in
gender-specific differences in cardiovascular diseases. One possible cardioprotective …

Adapter proteins and promoter regulation of the angiotensin AT2 receptor—implications for cardiac pathophysiology

H Funke-Kaiser, J Reinemund… - Journal of the Renin …, 2010 - journals.sagepub.com
The angiotensin AT 2 receptor (AT2R) represents an important component of the renin-
angiotensin system since it is involved in the (patho) physiology of different cardiovascular …

The importance of angiotensin II subtype receptors for blood pressure control during mouse pregnancy

K Chen, DC Merrill, JC Rose - Reproductive Sciences, 2007 - journals.sagepub.com
Pregnancy is characterized by a progressive increase in the di ferent components of the
renin angiotensin system (RAS) including angiotensin II, a potent vasoconstrictor. Pregnant …

The effect of renin angiotensin system on tamoxifen resistance

S Namazi, S Ardeshir-Rouhani-Fard, H Abedtash - Medical Hypotheses, 2011 - Elsevier
Breast cancer is one of the most common forms of cancer observed in women and
endogenous estrogens are thought to play a major role in its development. Tamoxifen is a …

Type 1 Angiotensin Receptor (AT1‐R)‐Mediated Decrease in Type 2 Angiotensin Receptor mRNA Level is Dependent on Gq and Extracellular Signal‐Regulated …

M Saito, Y Shinohara, H Sasaki, Y Netsu… - Journal of …, 2008 - Wiley Online Library
Angiotensin II (Ang II) functions through two major Ang II receptor subtypes, type 1 (AT1‐R)
and type 2 (AT2‐R), both of which are classified to be G protein‐coupled receptors. AT2‐R is …