Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications

MP Dandekar, AJ Fenoy, AF Carvalho, JC Soares… - Molecular …, 2018 - nature.com
Although deep brain stimulation (DBS) is an established treatment choice for Parkinson's
disease (PD), essential tremor and movement disorders, its effectiveness for the …

[HTML][HTML] Deep brain stimulation targets for treating depression

D Drobisz, A Damborská - Behavioural brain research, 2019 - Elsevier
Deep brain stimulation (DBS) is a new therapeutic approach for treatment-resistant
depression (TRD). There is a preliminary evidence of the efficacy and safety of DBS for TRD …

Deep brain stimulation of the “medial forebrain bundle”: a strategy to modulate the reward system and manage treatment-resistant depression

AJ Fenoy, J Quevedo, JC Soares - Molecular Psychiatry, 2022 - nature.com
The medial forebrain bundle—a white matter pathway projecting from the ventral tegmental
area—is a structure that has been under a lot of scrutinies recently due to its implications in …

The medial forebrain bundle as a target for deep brain stimulation for obsessive-compulsive disorder

VA Coenen, TE Schlaepfer, P Goll, PC Reinacher… - CNS …, 2017 - cambridge.org
Deep brain stimulation (DBS) is a promising putative modality for the treatment of refractory
psychiatric disorders such as major depression and obsessive-compulsive disorder (OCD) …

Functional circuitry effect of ventral tegmental area deep brain stimulation: imaging and neurochemical evidence of mesocortical and mesolimbic pathway modulation

ML Settell, P Testini, S Cho, JH Lee, CD Blaha… - Frontiers in …, 2017 - frontiersin.org
Background: The ventral tegmental area (VTA), containing mesolimbic and mesocortical
dopaminergic neurons, is implicated in processes involving reward, addiction …

Neuromodulation in psychiatric disorders: experimental and clinical evidence for reward and motivation network deep brain stimulation: focus on the medial forebrain …

MD Döbrössy, C Ramanathan… - European Journal of …, 2021 - Wiley Online Library
Deep brain stimulation (DBS) in psychiatric illnesses has been clinically tested over the past
20 years. The clinical application of DBS to the superolateral branch of the medial forebrain …

[HTML][HTML] Integrated pathophysiology of schizophrenia, major depression, and bipolar disorder as monoamine axon disorder

S Nakamura - Frontiers in Bioscience-Scholar, 2022 - imrpress.com
Recent studies provide evidence that similar to early-stage Parkinson's disease, depression
is a neurodegenerative disease characterized by the degeneration of monoamine axons …

Medial forebrain bundle deep brain stimulation reverses anhedonic-like behavior in a chronic model of depression: importance of BDNF and inflammatory cytokines

MP Dandekar, A Saxena, G Scaini, JH Shin… - Molecular …, 2019 - Springer
Deep brain stimulation (DBS) of the medial forebrain bundle (MFB) displays a promising
antidepressant effects in patients with treatment-refractory depression; however, a clear …

Application of neurotoxin-induced animal models in the study of Parkinson's disease-related depression: profile and proposal

YK Mou, LN Guan, XY Yao, JH Wang… - Frontiers in Aging …, 2022 - frontiersin.org
Depression can be a non-motor symptom, a risk factor, and even a co-morbidity of
Parkinson's disease (PD). In either case, depression seriously affects the quality of life of PD …

Increased dopamine receptor expression and anti-depressant response following deep brain stimulation of the medial forebrain bundle

MP Dandekar, D Luse, C Hoffmann, P Cotton… - Journal of affective …, 2017 - Elsevier
Background Among several potential neuroanatomical targets pursued for deep brain
stimulation (DBS) for treating those with treatment-resistant depression (TRD), the …