Tandem DNA repeats derived from the ancestral (TTAGGG) n run were first detected at
chromosome ends of the majority of living organisms, hence the name telomeric DNA …

The vast body of literature regarding human telomere maintenance is a true testament to the
importance of understanding telomere regulation in both normal and diseased states. In this …

DNA double-strand breaks (DSBs) must be repaired to ensure cell survival and genomic
integrity. In yeast, the Mre11-Rad50-Xrs2 complex (MRX) collaborates with Sae2 to initiate …

Telomeres are copied and reassembled each cell division cycle through a multistep process
called telomere replication. Most telomeric DNA is duplicated semiconservatively during this …

Telomeric DNA sequences are difficult to replicate. Replication forks frequently pause or
stall at telomeres, which can lead to telomere truncation and dysfunction. In addition to being …

During nuclear DNA replication multiprotein replisome machines have to jointly traverse and
duplicate the total length of each chromosome during each cell cycle. At certain genomic …

DNA loop extrusion by SMC proteins is a key process underlying chromosomal
organization. It is unknown how loop extruders interact with telomeres where chromosome …

Break-induced replication (BIR) is a mechanism used to heal one-ended DNA double-strand
breaks, such as those formed at collapsed replication forks or eroded telomeres. Instead of …

In many organisms, telomeric sequences can be located internally on the chromosome in
addition to their usual positions at the ends of the chromosome. In humans, such interstitial …

In budding yeast, Cdc13, Stn1, and Ten1 form the telomere-binding heterotrimer CST
complex. Here we investigate the role of Cdc13/CST in maintaining genome stability by …