Availability of artificial light and light-emitting devices have altered human temporal life,
allowing 24-hour healthcare, commerce and production, and expanding social life around …

Melatonin (MT) is a pleiotropic molecule with diverse and numerous actions both in plants
and animals. In plants, MT acts as an excellent promotor of tolerance against abiotic stress …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Melatonin, a derivative of an essential amino acid, tryptophan, was first identified in bovine
pineal tissue and subsequently it has been portrayed exclusively as a hormone. Recently …

Melatonin is an evolutionarily conserved molecule that serves a time-keeping function in
various species. In vertebrates, melatonin is produced predominantly by the pineal gland …

Introduction 3. Melatonin receptors 3.1. MT1 and MT2 melatonin receptors 3.1. 1. Molecular
structure 3.1. 2. Pharmacology 3.1. 2.1. Efficacy, potency and affinity 3.1. 2.2. Ligand …

The pineal hormone, melatonin, is an important regulator of seasonal reproduction and
circadian rhythms. Its effects are mediated via high-affinity melatonin receptors, located on …

The aim of this study was to identify the melatonin receptor type (s)(MT1 or MT2) mediating
circadian clock resetting by melatonin in the mammalian suprachiasmatic nucleus (SCN) …

There is growing evidence demonstrating the complexity of melatonin's role in modulating a
diverse number of physiological processes. This complexity could be attributed to the fact …

Two high-affinity, G protein-coupled melatonin receptor subtypes have been identified in
mammals. Targeted disruption of the Mel1a melatonin receptor prevents some, but not all …