Mast cells are well accepted as important sentinel cells for host defence against selected
pathogens. Their location at mucosal surfaces and ability to mobilize multiple aspects of …

Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) have co-evolved with humans for
thousands of years and are present at a high prevalence in the population worldwide. HSV …

Mast cells (MCs) are strategically located in tissues close to the external environment, being
one of the first immune cells to interact with invading pathogens. They are long living effector …

SUMMARY Human alphaherpesvirus 1 (HSV-1) is a highly successful neurotropic pathogen
that primarily infects the epithelial cells lining the orofacial mucosa. After primary lytic …

Neutrophils are the most abundant leukocyte in humans and they are among the first white
cells recruited to infected tissues. These leukocytes are essential for the innate immune …

Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells that
are well described as potent immune regulatory cells during human cancer and murine …

Abstract HSV type 1 (HSV-1) is one of the leading etiologies of sporadic viral encephalitis.
Early antiviral intervention is crucial to the survival of herpes simplex encephalitis patients; …

Dry eye disease (DED) is the most common ocular disease and affects millions of
individuals worldwide. DED encompasses a heterogeneous group of diseases that can be …

Herpes simplex virus type 1 (HSV-1) infection of the cornea induces vascular endothelial
growth factor A (VEGF-A)-dependent lymphangiogenesis that continues to develop well …

Whether complement dysregulation directly contributes to the pathogenesis of peripheral
nervous system diseases, including sensory neuropathies, is unclear. We addressed this …