Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread
A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) could be small interfering (si) RNAs. So far it is unclear, which viral replication steps …
CoV-2) could be small interfering (si) RNAs. So far it is unclear, which viral replication steps …
Nucleic acid-based treatments against COVID-19: potential efficacy of aptamers and siRNAs
Despite significant efforts, there are currently no approved treatments for COVID-19.
However, biotechnological approaches appear to be promising in the treatment of the …
However, biotechnological approaches appear to be promising in the treatment of the …
Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19
Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with
similar circulating CC levels present with different disease severity. Here, we determined …
similar circulating CC levels present with different disease severity. Here, we determined …
Non-coding RNA in idiopathic interstitial pneumonia and Covid-19 pulmonary fibrosis
Pulmonary fibrosis is the key feature of majority of idiopathic interstitial pneumonias (IIPs) as
well as many patients with post-COVID-19. The pathogenesis of pulmonary fibrosis is a …
well as many patients with post-COVID-19. The pathogenesis of pulmonary fibrosis is a …
[HTML][HTML] Lung-targeted delivery of nsp12 siRNAs restores host type I interferon responses
X Lan, H Li, J Guo, C Feng, X Zhou, J Wang, D Li… - Chemical Engineering …, 2024 - Elsevier
The RNA-dependent RNA polymerase (RdRp) of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), known as nsp12, is crucial to viral replication and spread …
coronavirus 2 (SARS-CoV-2), known as nsp12, is crucial to viral replication and spread …
Antisense technology as a potential strategy for the treatment of coronaviruses infection: With focus on COVID‐19
SH Alavizadeh, M Doagooyan… - IET …, 2022 - Wiley Online Library
After the outbreak of coronavirus disease 2019 (COVID‐19) in December 2019 and the
increasing number of SARS‐CoV‐2 infections all over the world, researchers are struggling …
increasing number of SARS‐CoV‐2 infections all over the world, researchers are struggling …
Studying miRNA–mRNA Interactions: An Optimized CLIP-Protocol for Endogenous Ago2-Protein
S Stebel, J Breuer, O Rossbach - Methods and Protocols, 2022 - mdpi.com
Transcriptome-wide analysis of RNA-binding partners is commonly achieved using UV
crosslinking and immunoprecipitation (CLIP). Individual-nucleotide-resolution CLIP (iCLIP) …
crosslinking and immunoprecipitation (CLIP). Individual-nucleotide-resolution CLIP (iCLIP) …
[HTML][HTML] BIOINFORMATIC APPROACHES IN STUDY OF MIRNA INTERACTION WITH THE GENOMES OF THE SARS-COV-2, MERS-COV, AND SARS-COV
The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus has resulted in numerous
deaths in many countries around the world. Vaccination of the population reduces mortality …
deaths in many countries around the world. Vaccination of the population reduces mortality …