Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

The proprotein convertase subtilisin/kexin-type 9 (PCSK9) binds to low-density lipoprotein
receptors (LDLR), thereby trafficking them to lysosomes upon endocytosis and enhancing …

In recent years, researchers have become focused on the relationship between lipids and
bone metabolism balance. Moreover, many diseases related to lipid metabolism disorders …

Natural products possess pleiotropic cardiovascular protective effects owing to their anti-
oxidation, anti-inflammation and anti-thrombotic properties. Kaempferol,(3, 5, 7-trihydroxy-2 …

Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is secreted mostly by hepatocytes
and to a lesser extent by the intestine, pancreas, kidney, adipose tissue, and vascular cells …

Cellular lipid membranes serve as the primary barrier preventing viral infection of the host
cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize …

Immunotherapy especially immune checkpoint inhibitors (ICIs) has brought favorable clinical
results for numerous cancer patients. However, the efficacy of ICIs in colorectal cancer …

Background: High blood cholesterol accelerates the progression of atherosclerosis, which is
an asymptomatic process lasting for decades. Rupture of atherosclerotic plaques induces …

Idiopathic pulmonary fibrosis (IPF) is a chronic irreversible interstitial lung disease
characterized by a progressive decline in lung function. The etiology of IPF is unknown …

Aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that binds
to low-density lipoprotein receptors. Efferocytosis is the process by which phagocytes …