Nephritis is one of the most severe complications of systemic lupus erythematosus (SLE).
One key characteristic of lupus nephritis (LN) is the deposition of immune complexes …

BACKGROUND: Methods to detect anti-nucleosome antibodies (ANuA) have been available
for more than 10years and the test has demonstrated its good sensitivity and high specificity …

Introduction Autoreactivity to histones is a pervasive feature of several human autoimmune
disorders, including systemic lupus erythematosus (SLE). Specific post-translational …

Although they are one of the oldest family of proteins known (first described in 1884 by
Kossel), histones continue to surprise researchers with their ever expanding roles in biology …

Objective Systemic lupus erythematosus (SLE) is characterized by the production of
antibodies against self antigens. However, the events underlying autoantibody formation in …

There is no serologic test that reliably measures disease activity in systemic lupus
erythematosus (SLE). The 'gold standard'is the anti-dsDNA antibody test, which has been …

Introduction Previous studies of anti‐dsDNA, nucleosome (Nucl), histone (His), and C1q
antibodies have revealed their clinical value in systemic lupus erythematosus (SLE) …

Age‐related macular maculopathy (ARM) and age‐related macular degeneration (AMD) are
the leading causes of blindness in the Western world. Despite the magnitude of this clinical …

Epigenetics is defined as the study of all inheritable and potentially reversible changes in
genome function that do not alter the nucleotide sequence within the DNA. Epigenetic …

Anti-chromatin (nucleosome) autoantibodies were one of the first autoantibodies ever
detected since they make up the majority of antibodies causing LE Cell formation. The …