Nanoparticles have been widely applied as gene carrier for improving RNA interference
(RNAi) efficiency in medical and agricultural fields. However, the mechanism and delivery …

Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-
AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the …

Chlamydia trachomatis (Ct) is an intracellular bacterial pathogen that relies on the activity of
secreted proteins known as effectors to promote replication and avoidance of immune …

ADP-ribosylation factor (ARF) GTPases are major regulators of cellular membrane
homeostasis. High sequence similarity and multiple, possibly redundant functions of the five …

Breast cancer (BC) is the most common type of cancer in women, and remains one of the
major causes of death in women worldwide. It is now well established that alterations in …

The family of Ras-like GTPases consists of over 150 different members, regulated by an
even larger number of guanine exchange factors (GEFs) and GTPase-activating proteins …

The late stages of Golgi maturation involve a series of sequential trafficking events in which
cargo-laden vesicles are produced and targeted to multiple distinct subcellular destinations …

Endocytosis and recycling control the uptake and retrieval of various materials, including
membrane proteins and lipids, in all eukaryotic cells. These processes are crucial for cell …

Mirror movements (MM) disorder is characterized by involuntary movements on one side of
the body that mirror intentional movements on the opposite side. We performed genetic …

The Golgi complex is the central sorting station of the eukaryotic secretory pathway. Traffic
through the Golgi requires activation of Arf guanosine triphosphatases that orchestrate cargo …