Large amounts of energy are required to maintain the signaling activities of CNS cells.
Because of the fine-grained heterogeneity of brain and the rapid changes in energy …

An emerging view emphasizes that metabolism is highly regulated in both time and space.
In addition, it is increasingly being recognized that metabolic pathways are tightly connected …

Changes in neuronal activity create local and transient changes in energy demands at
synapses. Here we discover a metabolic compartment that forms in vivo near synapses to …

The metabolic adaptation of eukaryotic cells to hypoxia involves increasing dependence
upon glycolytic adenosine triphosphate (ATP) production, an event with consequences for …

Glycolysis is upregulated under conditions such as hypoxia and high energy demand to
promote cell proliferation, although the mechanism remains poorly understood. We find that …

Summary The ATP-sensitive K+(K ATP) channel is a key regulator of hormone secretion
from pancreatic islet endocrine cells. Using direct measurements of K ATP channel activity in …

The published experimental data and existing concepts of cellular regulation of respiration
are analyzed. Conventional, simplified considerations of regulatory mechanism by …

Sarcoplasmic protein diffusion was studied under different conditions, using microinjection
in combination with microspectrophotometry. Six globular proteins with molecular masses …

Glycolysis is a highly conserved metabolic pathway responsible for the anaerobic
production of adenosine triphosphate (ATP) from the breakdown of glucose molecules …

Although much is known about the biochemical regulation of glycolytic enzymes, less is
understood about how they are organized inside cells. We systematically examine the …