Conserved binding regions provide the clue for peptide-based vaccine development: a chemical perspective

H Curtidor, C Reyes, A Bermúdez, M Vanegas… - Molecules, 2017 - mdpi.com
Synthetic peptides have become invaluable biomedical research and medicinal chemistry
tools for studying functional roles, ie, binding or proteolytic activity, naturally-occurring …

A hidden element governing immunogenicity in tumoral neoepitopes

EC Antonio, GF Vieira - Medical Hypotheses, 2024 - Elsevier
The search for what characteristics define an epitope as either an immunogenic or a non-
responsive target for immunotherapy has eluded researchers for years. Several studies …

抗原肽与MHC 分子相互作用QM/MM 分子动力学模拟研究

冯石磊, 胡墅, 刘兵, 刘伟 - 化学学报, 2013 - sioc-journal.cn
摘要在MHC I 类(major histocompatibility complex class I) 分子抗原加工提呈过程中抗原蛋白
在抗原提呈细胞(antigen-presenting cells, APC) 的胞浆中被蛋白酶体(proteasome) …

[PDF][PDF] Amino acids at positions 30β1 and 57β1 of HLA-DR confer susceptibility to or protection from chronic hepatitis B virus infection

Y Xia, W Sun, X Li, HY Wang, XY Yu, X Jin… - International Journal of …, 2016 - e-century.us
This study is to investigate whether structures and electrostatic potentials of human
leukocyte antigen (HLA)-DRB1 molecules are relative to the outcomes of hepatitis B virus …

Síntesis y determinación estructural de péptidos derivados de Dermaseptina con actividad antileishmanial

CA Rodríguez Vega - 2011 - repositorio.unal.edu.co
En este estudio se sintetizaron 11 péptidos con posible actividad biológica contra
Leishmania panamensis por medio de síntesis de péptidos en fase sólida (SPPS), a partir …

QM/MM Molecular Dynamics Simulation for the MHC class I Molecule Interacting with Antigen Peptide

S Feng, S Hu, B Liu, W Liu - Acta Chimica Sinica, 2013 - sioc-journal.cn
In the process of antigen presenting of major histocompatibility complex (MHC) class I
molecule, antigen protein, which is in the cytoplasm of antigen-presenting cells (APC), is …