Biomaterials: foreign bodies or tuners for the immune response?

E Mariani, G Lisignoli, RM Borzì… - International journal of …, 2019 - mdpi.com
The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

The toxicity of silica nanoparticles to the immune system

L Chen, J Liu, Y Zhang, G Zhang, Y Kang, A Chen… - …, 2018 - Taylor & Francis
Silicon-based materials and their oxides are widely used in drug delivery, dietary
supplements, implants and dental fillers. Silica nanoparticles (SiNPs) interact with …

Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses

L Deng, T Mohan, TZ Chang, GX Gonzalez… - Nature …, 2018 - nature.com
Current influenza vaccines provide limited protection against circulating influenza A viruses.
A universal influenza vaccine will eliminate the intrinsic limitations of the seasonal flu …

Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine

JI Andorko, CM Jewell - Bioengineering & translational …, 2017 - Wiley Online Library
Recent research in the vaccine and immunotherapy fields has revealed that biomaterials
have the ability to activate immune pathways, even in the absence of other immune …

Identification of QS-21 as an inflammasome-activating molecular component of saponin adjuvants

R Marty-Roix, GI Vladimer, K Pouliot, D Weng… - Journal of Biological …, 2016 - ASBMB
Many immunostimulants act as vaccine adjuvants via activation of the innate immune
system, although in many cases it is unclear which specific molecules contribute to the …

Immunologically effective biomaterials

Q Wei, Y Su, H Xin, L Zhang, J Ding… - ACS Applied Materials & …, 2021 - ACS Publications
Immunoregulation represents a booming field of biomaterial design. The unique physical
and chemical properties of biomaterials offer tremendous opportunities for development …

Polyelectrolyte multilayers assembled entirely from immune signals on gold nanoparticle templates promote antigen-specific T cell response

P Zhang, YC Chiu, LH Tostanoski, CM Jewell - Acs Nano, 2015 - ACS Publications
Materials that allow modular, defined assembly of immune signals could support a new
generation of rationally designed vaccines that promote tunable immune responses. Toward …

[HTML][HTML] Surface bisphosphonation of polyetheretherketone to manipulate immune response for advanced osseointegration

W Zhang, L Liu, H Zhou, C He, X Yang, J Fu, H Wang… - Materials & Design, 2023 - Elsevier
Polyetheretherketone (PEEK) is deemed to be a promising alternative to biomedical metals
for orthopedic and dental implantation attributed to its bone-like elastic modulus and good …

Next-generation biomaterials for dental pulp tissue immunomodulation

R Dal-Fabbro, WB Swanson, LC Capalbo, H Sasaki… - Dental Materials, 2023 - Elsevier
Objectives The current standard for treating irreversibly damaged dental pulp is root canal
therapy, which involves complete removal and debridement of the pulp space and filling with …

Inflammasome-mediated immunogenicity of clinical and experimental vaccine adjuvants

S Reinke, A Thakur, C Gartlan, JS Bezbradica, A Milicic - Vaccines, 2020 - mdpi.com
In modern vaccines, adjuvants can be sophisticated immunological tools to promote robust
and long-lasting protection against prevalent diseases. However, there is an urgent need to …