Integrating blood cell mechanics, platelet adhesive dynamics and coagulation cascade for modelling thrombus formation in normal and diabetic blood
Normal haemostasis is an important physiological mechanism that prevents excessive
bleeding during trauma, whereas the pathological thrombosis especially in diabetics leads …
bleeding during trauma, whereas the pathological thrombosis especially in diabetics leads …
Penetration of nanoparticles across a lipid bilayer: effects of particle stiffness and surface hydrophobicity
S Wang, H Guo, Y Li, X Li - Nanoscale, 2019 - pubs.rsc.org
The cellular uptake of nanoparticles (NPs) has drawn significant attention due to their great
importance and potential in drug delivery, bioimaging, and specific targeting. Here, we …
importance and potential in drug delivery, bioimaging, and specific targeting. Here, we …
An introductory overview of image-based computational modeling in personalized cardiovascular medicine
Cardiovascular diseases account for the number one cause of deaths in the world. Part of
the reason for such grim statistics is our limited understanding of the underlying mechanisms …
the reason for such grim statistics is our limited understanding of the underlying mechanisms …
A coarse-grained red blood cell membrane model to study stomatocyte-discocyte-echinocyte morphologies
An improved red blood cell (RBC) membrane model is developed based on the bilayer
coupling model (BCM) to accurately predict the complete sequence of stomatocyte-discocyte …
coupling model (BCM) to accurately predict the complete sequence of stomatocyte-discocyte …
Single-cell characterization of deformation and dynamics of mesenchymal stem cells in microfluidic systems: A computational study
Understanding the homing dynamics of individual mesenchymal stem cells (MSCs) in
physiologically relevant microenvironments is crucial for improving the efficacy of MSC …
physiologically relevant microenvironments is crucial for improving the efficacy of MSC …
Multiphysics and multiscale modeling of microthrombosis in COVID-19
Emerging clinical evidence suggests that thrombosis in the microvasculature of patients with
Coronavirus disease 2019 (COVID-19) plays an essential role in dictating the disease …
Coronavirus disease 2019 (COVID-19) plays an essential role in dictating the disease …
Synergistic integration of laboratory and numerical approaches in studies of the biomechanics of diseased red blood cells
In red blood cell (RBC) disorders, such as sickle cell disease, hereditary spherocytosis, and
diabetes, alterations to the size and shape of RBCs due to either mutations of RBC proteins …
diabetes, alterations to the size and shape of RBCs due to either mutations of RBC proteins …
Quantitative prediction of flow dynamics and mechanical retention of surface-altered red blood cells through a splenic slit
Normal red blood cells (RBCs) have remarkable properties of deformability, which enable
them to squeeze through tiny splenic inter-endothelial slits (IESs) without any damage …
them to squeeze through tiny splenic inter-endothelial slits (IESs) without any damage …
Modeling of biomechanics and biorheology of red blood cells in type 2 diabetes mellitus
Erythrocytes in patients with type-2 diabetes mellitus (T2DM) are associated with reduced
cell deformability and elevated blood viscosity, which contribute to impaired blood flow and …
cell deformability and elevated blood viscosity, which contribute to impaired blood flow and …
Computational investigation of blood cell transport in retinal microaneurysms
Microaneurysms (MAs) are one of the earliest clinically visible signs of diabetic retinopathy
(DR). MA leakage or rupture may precipitate local pathology in the surrounding neural retina …
(DR). MA leakage or rupture may precipitate local pathology in the surrounding neural retina …