Even among genetically identical cancer cells, resistance to therapy frequently emerges
from a small subset of those cells,,,,,–. Molecular differences in rare individual cells in the …

Breast cancer (BC) is characterized by an extensive genotypic and phenotypic
heterogeneity. In-depth investigations into the molecular bases of BC phenotypes …

Individual cells within an otherwise genetically homogenous population constantly undergo
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …

Aneuploid epithelial cells are common in breast cancer,; however, their presence in normal
breast tissues is not well understood. To address this question, we applied single-cell DNA …

Single-cell RNA sequencing (scRNA-seq) datasets contain true single cells, or singlets, in
addition to cells that coalesce during the protocol, or doublets. Identifying singlets with high …

Even amongst genetically identical cancer cells, therapy resistance often only emerges from
a very small subset of those cells. Much effort has gone into uncovering the molecular …

Chromosomal structural variation (SV) encompasses a heterogenous class of genetic
variants that exerts strong influences on human health and disease. Despite their …

Despite insights gained by bulk DNA sequencing of cancer it remains challenging to resolve
the admixture of normal and tumor cells, and/or of distinct tumor subclones; high-throughput …

Understanding transcriptional heterogeneity in cancer cells and its implication for treatment
response is critical to identify how resistance occurs and may be targeted. Such …

The applications of single-cell and spatial technologies in recent times have revolutionized
the present understanding of cellular states and the cellular heterogeneity inherent in …