Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria

SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

The rough guide to monocytes in malaria infection

A Ortega-Pajares, SJ Rogerson - Frontiers in immunology, 2018 - frontiersin.org
While half of the world's population is at risk of malaria, the most vulnerable are still children
under five, pregnant women and returning travelers. Anopheles mosquitoes transmit malaria …

Protective immunity against severe malaria in children is associated with a limited repertoire of antibodies to conserved PfEMP1 variants

SK Tessema, R Nakajima, A Jasinskas, SL Monk… - Cell host & …, 2019 - cell.com
Extreme diversity of the major Plasmodium falciparum antigen, PfEMP1, poses a barrier to
identifying targets of immunity to malaria. Here, we used protein microarrays containing …

Antibody Targets on the Surface of Plasmodium falciparum–Infected Erythrocytes That Are Associated With Immunity to Severe Malaria in Young Children

JA Chan, MJ Boyle, KA Moore, L Reiling… - The Journal of …, 2019 - academic.oup.com
Abstract Background Sequestration of Plasmodium falciparum–infected erythrocytes (IEs) in
the microvasculature contributes to pathogenesis of severe malaria in children. This …

Mediterranean diet: lipids, inflammation, and malaria infection

AR Silva, BPT Moraes… - International journal of …, 2020 - mdpi.com
The Mediterranean diet (MedDiet) consists of consumption of vegetables and healthy oils
and have beneficial effects on metabolic and inflammatory diseases. Our goal here is to …

[HTML][HTML] Longitudinal analysis of naturally acquired PfEMP1 CIDR domain variant antibodies identifies associations with malaria protection

N Obeng-Adjei, DB Larremore, L Turner, A Ongoiba… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Malaria pathogenicity is determined, in part, by the adherence of
Plasmodium falciparum–infected erythrocytes to the microvasculature mediated via specific …

Antibody to Plasmodium falciparum Variant Surface Antigens, var Gene Transcription, and ABO Blood Group in Children With Severe or Uncomplicated Malaria

P Barua, MF Duffy, L Manning, M Laman… - The Journal of …, 2023 - academic.oup.com
Background Antibodies to variant surface antigens (VSAs) such as Plasmodium falciparum
erythrocyte membrane protein 1 (PfEMP1) may vary with malaria severity. The influence of …

Declining Malaria Transmission Differentially Impacts the Maintenance of Humoral Immunity to Plasmodium falciparum in Children

CK Mugyenyi, SR Elliott, XZ Yap, G Feng… - The Journal of …, 2017 - academic.oup.com
Background We investigated the poorly understood impact of declining malaria transmission
on maintenance of antibodies to Plasmodium falciparum merozoite antigens and infected …

The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children

P Barua, JG Beeson, K Maleta, P Ashorn, SJ Rogerson - Malaria Journal, 2019 - Springer
Background Antibodies targeting malaria blood-stage antigens are important targets of
naturally acquired immunity, and may act as valuable biomarkers of malaria exposure …