All species continuously evolve short open reading frames (sORFs) that can be templated
for protein synthesis and may provide raw materials for evolutionary adaptation. We …

Abstract Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of
the human genome and proteome by illuminating thousands of noncanonical sites of …

Efforts to precisely identify tumor human leukocyte antigen (HLA) bound peptides capable of
mediating T cell-based tumor rejection still face important challenges. Recent studies …

Mutations in the RNA helicase, DDX3X, are a leading cause of Intellectual Disability and
present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical …

A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation.
Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively …

DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X-and
Y-linked paralogs DDX3X and DDX3Y. While DDX3X is ubiquitously expressed in human …

Many cancers are characterized by gene fusions encoding oncogenic chimeric transcription
factors (TFs) such as EWS:: FLI1 in Ewing sarcoma (EwS). Here, we find that EWS:: FLI1 …

DDX3 is an RNA chaperone of the DEAD-box family that regulates translation. Ded1, the
yeast ortholog of DDX3, is a global regulator of translation, whereas DDX3 is thought to …

Since the introduction of the ribosome profiling technique in 2009 its popularity has greatly
increased. It is widely used for the comprehensive assessment of gene expression and for …

Translation modulates the timing and amplification of gene expression after transcription.
Brain development requires uniquely complex gene expression patterns, but large-scale …