I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Chronic rhinosinusitis (CRS) is a common clinical syndrome that produces significant
morbidity and costs to our health system. The study of CRS has progressed from an era …

Contributing Authors Isam Alobid, MD, PhD1, Nithin D. Adappa, MD2, Henry P. Barham,
MD3, Thiago Bezerra, MD4, Nadieska Caballero, MD5, Eugene G. Chang, MD6, Gaurav …

Chronic rhinosinusitis (CRS) is a complex heterogeneous disease with different phenotypes
and endotypes. Recent advances in our understanding of the pathogenetic mechanisms of …

Background Persistent mucosal inflammation in patients with chronic rhinosinusitis (CRS)
often results in ongoing symptoms, recurrence of polypoid mucosa, infective exacerbations …

Endonasal endoscopic sinus surgery is the standard procedure for surgery of most
paranasal sinus diseases. Appropriate frame conditions provided, the respective procedures …

Objectives/Hypothesis The goal of the study was to perform a systematic review with meta‐
analysis to determine the mean change in the 22‐item Sino‐Nasal Outcome Test (SNOT …

Background Topical therapies have become an integral component in the management plan
for chronic rhinosinusitis (CRS). Several topical therapy strategies have been evaluated, but …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory
condition of nasal mucosa and paranasal sinuses, predominantly mediated by type 2 …

Background Chronic rhinosinusitis (CRS) is a complex disease that incorporates many
different conditions. Currently, primary CRS is considered a disease of broad airway …