Sponges (phylum Porifera) are sessile marine filter feeders that have developed efficient
defense mechanisms against foreign attackers such as viruses, bacteria, or eukaryotic …

Currently, one third of the world's population is infected with Mycobacterium tuberculosis
and 8.9–9.9 million new and relapse cases of tuberculosis are reported every year. The …

Microbial symbiotic communities of marine macro-organisms carry functional metabolic
profiles different to the ones found terrestrially and within surrounding marine environments …

The apparent predicament of the representative chemotherapy for managing respiratory
distress calls for an obligatory deliberation for identifying the pharmaceuticals that effectively …

Tuberculosis has been one of the greatest global health challenges of all time. Although the
current first-line anti-tuberculosis (anti-TB) medicines used in the clinic have reduced …

An increasing incidence of deaths due to tuberculosis and the known drawbacks of the
current existing drugs including the emergence of multi drug-resistant strains have led to a …

Despite of the advances made in the treatment and management, tuberculosis (TB) still
remains one of main public health problem. The contrary effects of first and second-line anti …

The curiosity and attention that researchers have devoted to alkaloids are due to their
bioactivities, structural diversity, and intriguing chemistry. Marine-derived macrocyclic …

Four bis-piperidine alkaloids, madangamine F (1), haliclonacyclamine F (2). and
arenosclerins D (3) and E (4), have been isolated from the marine sponge Pachychalina …

New therapeutics are urgently needed to combat the immense disease burden of
tuberculosis and related mycobacterial diseases worldwide. Natural products continue to …