A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Mechanisms of assembly and remodelling of the extracellular matrix

A Naba - Nature Reviews Molecular Cell Biology, 2024 - nature.com
The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …

The extracellular matrix as a multitasking player in disease

AD Theocharis, D Manou, NK Karamanos - The FEBS journal, 2019 - Wiley Online Library
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

Into the tissues: Extracellular matrix and its artificial substitutes: Cell signalling mechanisms

A Bandzerewicz, A Gadomska-Gajadhur - Cells, 2022 - mdpi.com
The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

[HTML][HTML] Elastic fibers during aging and disease

A Heinz - Ageing research reviews, 2021 - Elsevier
Elastic fibers are essential constituents of the extracellular matrix of higher vertebrates and
endow several tissues and organs including lungs, skin and blood vessels with elasticity …

Elastases and elastokines: elastin degradation and its significance in health and disease

A Heinz - Critical reviews in biochemistry and molecular biology, 2020 - Taylor & Francis
Elastin is an important protein of the extracellular matrix of higher vertebrates, which confers
elasticity and resilience to various tissues and organs including lungs, skin, large blood …

Elastic fibers: Formation, function, and fate during aging and disease

CEH Schmelzer, L Duca - The FEBS Journal, 2022 - Wiley Online Library
Elastic fibers are extracellular components of higher vertebrates and confer elasticity and
resilience to numerous tissues and organs such as large blood vessels, lungs, and skin …

ADAMTS proteases in cardiovascular physiology and disease

S Santamaria, R de Groot - Open biology, 2020 - royalsocietypublishing.org
The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family
comprises 19 proteases that regulate the structure and function of extracellular proteins in …

Tissue morphogenesis through dynamic cell and matrix interactions

D Wu, KM Yamada, S Wang - Annual Review of Cell and …, 2023 - annualreviews.org
Multicellular organisms generate tissues of diverse shapes and functions from cells and
extracellular matrices. Their adhesion molecules mediate cell-cell and cell-matrix …

[HTML][HTML] The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly

ARF Godwin, M Singh, MP Lockhart-Cairns, YF Alanazi… - Matrix Biology, 2019 - Elsevier
Fibrillin is a large evolutionarily ancient extracellular glycoprotein that assembles to form
beaded microfibrils which are essential components of most extracellular matrices. Fibrillin …