Interleukin-21 is a cytokine with broad pleiotropic actions that affect the differentiation and
function of lymphoid and myeloid cells. Since its discovery in 2000, a tremendous amount …

Interleukin‐(IL‐) 21 is a pleiotropic cytokine that regulates the activity of both innate and
specific immunity. Indeed, it costimulates T and natural killer (NK) cell proliferation and …

Chronic lymphocytic leukaemia (CLL) cells encounter T‐cells and proliferate in response to
T‐cell signals in the lymph node microenvironment. In this report we determined interleukin …

In a previous study, we detected a significant association between phosphoserine
aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen …

Serum cytokines and chemokines may reflect tumor biology and host response in follicular
lymphoma (FL). To determine whether the addition of these biological factors may further …

Oxymatrine (OMT) as a type of alkaloids collected from Sophora flavescens Ait exerts some
biological functions including anticancer properties. Here, we investigated the therapeutic …

Abstract Interleukin-21 receptor (IL-21R) is involved in the immunological regulation of
immune cells and tumor progression in multiple malignancies. However, the potential …

Introduction Recent evidence suggests that tumour lymphangiogenesis promotes lymph
node metastasis, a major prognostic factor for survival of breast cancer patients. However …

Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a
paradigm of immune tumor microenvironment (TME) contribution to disease onset …

Interleukin 21 (IL21) is a cytokine produced predominantly by cluster of differentiation 4
(CD4+) T-cells and natural killer T-cells. There exists evidence that IL21 is implicated in …