The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Multidrug-resistant, Gram-negative infection is a major global determinant of morbidity,
mortality and cost of care. The advent of nanomedicine has enabled tailored engineering of …

Inflammatory mediators increase vascular permeability primarily by formation of intercellular
gaps between endothelial cells of post-capillary venules. Under these conditions …

Apoptosis is an important biological process required for the removal of unwanted or
damaged cells. Mounting evidence implicates the actin cytoskeleton as both a sensor and …

Endothelial permeability depends on the integrity of intercellular junctions as well as
actomyosin-based cell contractility. Rho GTPases have been implicated in signalling by …

The expression of the monocyte chemoattractant protein-1 (MCP-1) receptor CCR2 by brain
endothelial cells suggests that MCP-1 may have other functions than purely driving …

We hypothesized that ultrafiltrate crossing the luminal endothelial glycocalyx through
infrequent discontinuities (gaps) in the tight junction (TJ) strand of endothelial clefts reduces …

Objective: To test the role of an oncotic pressure gradient across the endothelial glycocalyx
with respect to extravasation of fluid and colloids and development of tissue edema in a …

Much evidence indicates that cAMP-dependent protein kinase (PKA) prevents increased
endothelial permeability induced by inflammatory mediators. We investigated the hypothesis …

Monocyte chemoattractant protein-1 (MCP-1 or CCL2) regulates blood-brain barrier
permeability by inducing morphological and biochemical alterations in the tight junction (TJ) …