Activation of mechanosensitive ion channels underlies a variety of fundamental
physiological processes that require sensation of mechanical force. Different …

Brains contain networks of interconnected neurons and so knowing the network architecture
is essential for understanding brain function. We therefore mapped the synaptic-resolution …

Discussions of the function of early nervous systems usually focus on a causal flow from
sensors to effectors, by which an animal coordinates its actions with exogenous changes in …

Sound-induced mechanical stimuli are detected by elaborate mechanosensory transduction
(MT) machinery in highly specialized hair cells of the inner ear. Genetic studies of inherited …

Proprioceptors provide feedback about body position that is essential for coordinated
movement. Proprioceptive sensing of the position of rigid joints has been described in detail …

In multicellular lives, the differentiation of stem cells and progenitor cells is often
accompanied by a transition from glycolysis to mitochondrial oxidative phosphorylation …

Mechanotransduction channels have been proposed as force sensors in various
physiological processes, such as hearing and touch. In particular, TMC1 has been shown to …

Highlights•Drosophila larva enables combining comprehensive synapse resolution
connectivity maps with cellular-resolution activity maps and behavior maps.•This approach …

A repetitive gait cycle is an archetypical component within the behavioral repertoire of many
animals including humans. It originates from mechanical feedback within proprioceptors to …

In animals, proper locomotion is crucial to find mates and foods and avoid predators or
dangers. Multiple sensory systems detect external and internal cues and integrate them to …