SLC transporters as therapeutic targets: emerging opportunities
Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …
facilitate the transport of a wide array of substrates across biological membranes—have …
[HTML][HTML] A call for systematic research on solute carriers
A Cesar-Razquin, B Snijder, T Frappier-Brinton… - Cell, 2015 - cell.com
Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …
Post-translational modifications of transporters
Drug transporter proteins are critical to the distribution of a wide range of endogenous
compounds and xenobiotics such as hormones, bile acids, peptides, lipids, sugars, and …
compounds and xenobiotics such as hormones, bile acids, peptides, lipids, sugars, and …
SLC transporters: structure, function, and drug discovery
The human solute carrier (SLC) transporters are important targets for drug development.
Structure-based drug discovery for SLC transporters requires the description of their …
Structure-based drug discovery for SLC transporters requires the description of their …
[HTML][HTML] How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion
One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …
varying one or more independent variables, and assessing the effects of this variation on the …
The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid–sensing TLRs and ligands to endolysosomes
I Rimann, R Gonzalez-Quintial… - Proceedings of the …, 2022 - National Acad Sciences
A function-impairing mutation (feeble) or genomic deletion of SLC15A4 abolishes responses
of nucleic acid–sensing endosomal toll-like receptors (TLRs) and significantly reduces …
of nucleic acid–sensing endosomal toll-like receptors (TLRs) and significantly reduces …
[HTML][HTML] Cellular models and in vitro assays for the screening of modulators of P-gp, MRP1 and BCRP
M Gameiro, R Silva, C Rocha-Pereira, H Carmo… - Molecules, 2017 - mdpi.com
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are highly expressed in
tumor cells, as well as in organs involved in absorption and secretion processes, mediating …
tumor cells, as well as in organs involved in absorption and secretion processes, mediating …
Bypassing P‐glycoprotein drug efflux mechanisms: possible applications in Pharmacoresistant schizophrenia therapy
FG Hoosain, YE Choonara, LK Tomar… - BioMed research …, 2015 - Wiley Online Library
The efficient noninvasive treatment of neurodegenerative disorders is often constrained by
reduced permeation of therapeutic agents into the central nervous system (CNS). A vast …
reduced permeation of therapeutic agents into the central nervous system (CNS). A vast …
Models for drug absorption from the small intestine: where are we and where are we going?
Highlights•It is of primary importance to obtain relevant models in drug
discovery.•Physiology and biology of the oral route is complex to model.•In silico models …
discovery.•Physiology and biology of the oral route is complex to model.•In silico models …
OCTN: a small transporter subfamily with great relevance to human pathophysiology, drug discovery, and diagnostics
L Pochini, M Galluccio, M Scalise… - … the Science of Drug …, 2019 - journals.sagepub.com
OCTN is a small subfamily of membrane transport proteins that belongs to the larger SLC22
family. Two of the three members of the subfamily, namely, OCTN2 and OCTN1, are present …
family. Two of the three members of the subfamily, namely, OCTN2 and OCTN1, are present …