The field of Green Chemistry has seen many scientific discoveries and inventions during the
20 years since the 12 Principles were first published. Inspired by tree diagrams that illustrate …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …

In recent years many efforts have been devoted to the screening and the study of new solid-
state forms of old active pharmaceutical ingredients (APIs) with salification or co …

This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …

In recent years cocrystal formation has emerged as a viable strategy towards improving the
solubility and bioavailability of poorly soluble drugs. In this review the success of numerous …

A novel energetic cocrystal predicted to exhibit greater power and similar sensitivity to that of
the current military standard explosive 1, 3, 5, 7-tetranitro-1, 3, 5, 7-tetrazacyclooctane …

Generally speaking, molecular compounds have a strong tendency to have crystalline order
in the solid state. Amorphous materials do exist, of course, but they are rarely the most stable …

Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

" Polymorphism in the Pharmaceutical Industry-Solid Form and Drug Development"
highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus …