Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …

The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

The blood-brain barrier (BBB) tightly regulates the entry of solutes from blood into the brain
and is disrupted in several neurological diseases. Using Organ-Chip technology, we created …

Neurovascular inflammation is a major contributor to many neurological disorders, but
modeling these processes in vitro has proven to be difficult. Here, we microengineered a …

Glucose transporters (GLUTs) at the blood-brain barrier maintain the continuous high
glucose and energy demands of the brain. They also act as therapeutic targets and provide …

The blood-brain barrier (BBB), a unique selective barrier for the central nervous system
(CNS), hinders the passage of most compounds to the CNS, complicating drug …

The Blood–brain barrier (BBB), present at the level of the endothelium of cerebral blood
vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is …

Culture-based blood–brain barrier (BBB) models are crucial tools to enable rapid screening
of brain-penetrating drugs. However, reproducibility of in vitro barrier properties and …

The central nervous system, one of the most delicate microenvironments of the body, is
protected by the blood‐brain barrier (BBB) regulating its homeostasis. BBB is a highly …

The blood–brain barrier (BBB) is a dynamic and complex interface between blood and the
central nervous system that strictly controls the exchanges between the blood and brain …