Human induced pluripotent stem (iPS) cells derived from somatic cells hold promise to
develop novel patient-specific cell therapies and research models for inherited and acquired …

Accumulated data indicate that current generation lentiviral vectors, which generally utilize
an internal human cytomegalovirus (CMV) immediate early region enhancer–promoter to …

Lentiviral vectors are promising tools for the development of gene therapy since they can
transduce both quiescent and dividing target cells. Lentiviral vectors may be particularly …

Pulmonary hypertension (PH) is a leading cause of death in sickle cell disease (SCD)
patients. Hemolysis and oxidative stress contribute to SCD-associated PH. We have …

Hematopoietic stem cells (HSCs) represent an important target for the treatment of various
blood disorders. As the source of critical cells within the immune system, genetic …

CD34+ hematopoietic stem/progenitor cells (HSCs) reside in the bone marrow in close
proximity to the endosteal bone surface, surrounded by osteoblasts, stromal cells, and …

OBJECTIVES: The relationship between phenotype and function in ex vivo–cultured human
hematopoietic stem cells (HSC) remains poorly understood. We investigated the effects of a …

OBJECTIVE: In this study we compared the hematopoietic capacity of CD34+ cell
preparations from neonatal cord blood (CB) vs adult mobilized peripheral blood (PBSC) …

In umbilical cord blood (UCB) transplantation, the number of nucleated cells per kilogram is
a major predictive and critical factor of hematopoietic recovery. Thus, ex vivo expansion of …

Disease-specific induced pluripotent stem cells (iPSCs) provide an unprecedented
opportunity to establish novel disease models and accelerate drug development using …