Abstract Histone deacetylase 6 (HDAC6) is a class IIb histone deacetylase that contains two
catalytic domains and a zinc-finger ubiquitin binding domain (ZnF-UBP) domain. The …

Neuronal precursor cell-expressed developmentally down-regulated protein 8 (NEDD8) is a
ubiquitin-like protein (UBL) whose canonical function involves binding to, and thus …

Abstract Ubiquitin (Ub) and Ub-like proteins (Ubls) such as NEDD8 are best known for their
function as covalent modifiers of other proteins but they are also themselves subject to post …

Exploring the connection between ubiquitin-like modifiers (ULMs) and the DNA damage
response (DDR), we employed several advanced DNA damage and repair assay …

Mutations can disrupt the native function of protein by causing misfolding, which is generally
handled by an intricate protein quality control network. To better understand the triaging …

Post-translational modification of proteins with the Ubiquitin-like molecule NEDD8 is a
critical regulatory mechanism for several biological processes and a potential target for …

K63-linked polyubiquitination of the neurodegenerative disease-associated misfolded
protein copper-zinc superoxide dismutase 1 (SOD1) is associated with the formation of …

Ubiquitin-specific protease 8 is involved in endosomal/lysosomal trafficking, exerts multiple
cellular functions, and was identified as a vulnerability gene for multiple myeloma, a disease …

Neddylation is a post-translational modification that is essential for a variety of cellular
processes and is linked to many human diseases including cancer, neurodegeneration, and …

NF-kB driven cellular immunity is essential for both pro-and anti-inflammatory responses to
microbes, which makes it one of the most frequently targeted pathways by bacteria during …