Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

With the ability to resolve structures of macromolecules at atomic resolution, X‐ray
crystallography has been the most powerful tool in modern structural biology. At the same …

The type-1 ryanodine receptor (RyR1) is an intracellular calcium (Ca 2+) release channel
required for skeletal muscle contraction. Here, we present cryo-EM reconstructions of RyR1 …

Ryanodine receptors (RyRs) mediate the rapid release of calcium (Ca2+) from intracellular
stores into the cytosol, which is essential for numerous cellular functions including excitation …

Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca 2+) release channels
required for the function of many organs including heart and skeletal muscle, synaptic …

Pesticide researchers are students of nature, and each new compound and mechanism
turns a page in the ever-expanding encyclopedia of life. Pesticides are both probes to learn …

Aims Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an ion
channelopathy characterized by ventricular arrhythmia during exertion or stress. Mutations …

Abstract Ryanodine Receptors (RyRs) are massive channels that release Ca2+ from the
endoplasmic and sarcoplasmic reticulum. Hundreds of mutations are linked to malignant …

Mutations in ryanodine receptors (RyRs), intracellular Ca2+ channels, are associated with
deadly disorders. Despite abundant functional studies, the molecular mechanism of RyR …

Thermoregulation is an important aspect of human homeostasis, and high temperatures
pose serious stresses for the body. Malignant hyperthermia (MH) is a life-threatening …