The changing face of Turner syndrome

CH Gravholt, M Viuff, J Just, K Sandahl… - Endocrine …, 2023 - academic.oup.com
Turner syndrome (TS) is a condition in females missing the second sex chromosome (45, X)
or parts thereof. It is considered a rare genetic condition and is associated with a wide range …

Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation

I Gažová, A Lengeling, KM Summers - Molecular genetics and metabolism, 2019 - Elsevier
Histone demethylases remove transcriptional repressive marks from histones in the nucleus.
KDM6A (also known as UTX) is a lysine demethylase which acts on the trimethylated lysine …

[HTML][HTML] Brain disease network analysis to elucidate the neurological manifestations of COVID-19

K Prasad, SY AlOmar, SAM Alqahtani, MZ Malik… - Molecular …, 2021 - Springer
Although COVID-19 largely causes respiratory complications, it can also lead to various
extrapulmonary manifestations resulting in higher mortality and these comorbidities are …

[HTML][HTML] Organ abnormalities caused by Turner syndrome

SH Yoon, GY Kim, GT Choi, JT Do - Cells, 2023 - mdpi.com
Turner syndrome (TS), a genetic disorder due to incomplete dosage compensation of X-
linked genes, affects multiple organ systems, leading to hypogonadotropic hypogonadism …

[HTML][HTML] CDK1 and HSP90AA1 appear as the novel regulatory genes in non-small cell lung cancer: a bioinformatics approach

N Bhattacharyya, S Gupta, S Sharma, A Soni… - Journal of Personalized …, 2022 - mdpi.com
Lung cancer is one of the most invasive cancers affecting over a million of the population.
Non-small cell lung cancer (NSCLC) constitutes up to 85% of all lung cancer cases, and …

Network pharmacology and bioinformatics approach reveals the therapeutic mechanism of action of curcumin in Alzheimer disease

D Vijh, MA Imam, MMU Haque, S Das, A Islam… - Metabolic Brain …, 2023 - Springer
Curcumin is a natural anti-inflammatory and antioxidant substance which plays a major role
in reducing the amyloid plaques formation, which is the major cause of Alzheimer's disease …

[HTML][HTML] Kinless hubs are potential target genes in prostate cancer network

IR Mangangcha, MZ Malik, O Kucuk, S Ali, RKB Singh - Genomics, 2020 - Elsevier
Complex disease networks can be studied successfully using network theoretical approach
which helps in finding key disease genes and associated disease modules. We studied …

Network medicine in ovarian cancer: topological properties to drug discovery

K Chirom, MZ Malik, IR Mangangcha… - Briefings in …, 2022 - academic.oup.com
Network medicine provides network theoretical tools, methods and properties to study
underlying laws governing human interactome to identify disease states and disease …

[HTML][HTML] Identification of New Key genes and their association with breast Cancer occurrence and poor survival using in Silico and in Vitro methods

R Ali, A Sultan, R Ishrat, S Haque, NJ Khan, MA Prieto - Biomedicines, 2023 - mdpi.com
Breast cancer is one of the most prevalent types of cancer diagnosed globally and continues
to have a significant impact on the global number of cancer deaths. Despite all efforts of …

[HTML][HTML] Methodology of predicting novel key regulators in ovarian cancer network: a network theoretical approach

MZ Malik, K Chirom, S Ali, R Ishrat, P Somvanshi… - BMC cancer, 2019 - Springer
Background Identification of key regulator/s in ovarian cancer (OC) network is important for
potential drug target and prevention from this cancer. This study proposes a method to …