Aging is characterized by a deterioration in the maintenance of homeostatic processes over
time, leading to functional decline and increased risk for disease and death. The aging …

The insulin-like growth factor 1 (IGF1) signalling pathway has important roles in regulating
cellular proliferation and apoptosis. Converging results from epidemiological research and …

Caloric restriction extends healthy lifespan in multiple species. Intermittent fasting, an
alternative form of dietary restriction, is potentially more sustainable in humans, but its …

Maximum life span differences among animal species exceed life span variation achieved
by experimental manipulation by orders of magnitude. The differences in the characteristic …

It has been known for some 70 years that restricting the food intake of laboratory rats
extends their mean and maximum life span. In addition, such life extension has been …

Mice are increasingly used for investigation of the pathophysiology of osteoporosis because
their genome is easily manipulated, and their skeleton is similar to that of humans. Unlike …

The important role of GH in the control of mammalian longevity was first deduced from
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …

Aging in worms and flies is regulated by the PI3K/Akt/Foxo pathway. Here we extend this
paradigm to mammals. Pten tg mice carrying additional genomic copies of Pten are …

Growth hormone (GH) is a key determinant of postnatal growth and plays an important role
in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling …

The identification of genes and interventions that slow or reverse aging is hampered by the
lack of non-invasive metrics that can predict the life expectancy of pre-clinical models. Frailty …