A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

With the advent of mechanobiology, cell shape and forces have emerged as essential
elements of cell behavior and fate, in addition to biochemical factors such as growth factors …

Region-specific gut spheroids are precursors for gastrointestinal and pulmonary organoids
that hold great promise for fundamental studies and translations. However, efficient …

Micropatterning encompasses a set of methods aimed at precisely controlling the spatial
distribution of molecules onto the surface of materials. Biologists have borrowed the idea …

ABSTRACT A major factor driving stem cell decline is stem cell niche aging, but its
molecular mechanism remains elusive. We use the Caenorhabditis elegans distal tip cell …

The immense regenerative potential of the liver is attributed to the ability of its two key cell
types–hepatocytes and cholangiocytes–to trans-differentiate to one another either directly or …

During development, cell signaling instructs tissue patterning, the process by which initially
identical cells give rise to spatially organized structures consisting of different cell types …

The design of cell-instructive biomaterials for tissue engineering and regenerative medicine
is at a crossroads. Although the conventional tissue engineering approach is top-down (cells …

Cholangiocyte organoids can be used to model liver biliary disease; however, both a
defined matrix to emulate cholangiocyte self‐assembly and the mechano‐transduction …

Skeletal muscle regeneration remains a clinical unmet need for volumetric muscle loss and
atrophy where muscle function cannot be restored to prior capacity. Current experimental …