Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …

Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca,
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

Drugs that modulate serotonin (5-HT) synaptic concentrations impact neurogenesis and
hippocampal (HPC)-dependent learning. The primary objective is to determine the extent to …

The neurogenesis hypothesis of depression posits (1) that neurogenesis in the subgranular
zone of the dentate gyrus is regulated negatively by stressful experiences and positively by …

It was long thought that no new neurons are added to the adult brain. Similarly,
neurotransmitter signaling was primarily associated with communication between …

The original definition of atypical antipsychotic drugs (APD) was drugs that are effective
against positive symptoms in schizophrenia with no or little extrapyramidal symptoms (EPS) …

Schizophrenia is a widespread psychiatric disorder that affects 0.5–1.0% of the world's
population and induces significant, long-term disability that exacts high personal and …

Depression has emerged as a major cause of mortality globally. Many studies have reported
risk factors and mechanisms associated with depression, but it is as yet unclear how these …

Psychedelics are quite unique among drugs that impact the central nervous system, as a
single administration of a psychedelic can both rapidly alter subjective experience in …