E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …

Graphene oxide (GO) has attracted tremendous attention as a most promising nanomaterial
among the carbon family since it emerged as a polynomial functional tool with rational …

Aging is an important risk factor for several human diseases such as cancer, cardiovascular
disease and neurodegenerative disorders, resulting from a combination of genetic and …

One of the major challenges in our contemporary society is to facilitate healthy life for all
human beings. In this context, cancer has become one of the most deadly diseases around …

Despite decades of search for anticancer drugs targeting solid tumors, this group of
diseases remains largely incurable, especially if in advanced, metastatic stage. In this …

The epithelial–mesenchymal transition (EMT) is thought to be at the root of invasive and
metastatic cancer cell spreading. E-cadherin is an important player in this process, which …

Glutamate, a nonessential amino acid, is a major bioenergetic substrate for proliferating
normal and neoplastic cells on one hand and an excitatory neurotransmitter that is actively …

Studies of animals and plants suggest that nutritional conditions in one generation may
affect phenotypic characteristics in subsequent generations. A small number of human …

Cell cycle, growth, survival and metabolism are tightly regulated together and failure in
cellular regulation leads to carcinogenesis. Several signaling pathways like the PI3K, WNT …

DNA methylation, as an epigenetic mechanism, occurs by adding a methyl group of
cytosines in position 5 by DNA methyltransferases and has essential roles in cellular …