Natural products and their derivatives have historically been invaluable as a source of
therapeutic agents. However, in the past decade, research into natural products in the …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Throughout the ages, Nature has catered to the basic needs of humans, not the least of
which is the provision of medicines for the treatment of a wide spectrum of diseases. Plants …

Abstract The 3, 3′‐pyrrolidinyl‐spirooxindole unit is a privileged heterocyclic motif that
forms the core of a large family of alkaloid natural products with strong bioactivity profiles …

Biologically active molecules can be identified through the screening of small-molecule
libraries. Deficiencies in current compound collections are evidenced by the continuing …

Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …

There is mounting urgency to find new drugs for the treatment of serious infectious diseases
and cancer that are rapidly developing resistance to previously effective drugs. One …

Diversity-oriented synthesis (DOS) is an emerging field involving the synthesis of
combinatorial libraries of diverse small molecules for biological screening. Rather than …

Using a diverse collection of small molecules generated from a variety of sources, we
measured protein-binding activities of each individual compound against each of 100 …

Abstract Das 3, 3′‐Pyrrolidinylspirooxindol‐System ist ein privilegiertes heterocyclisches
Strukturmotiv, das die zentrale Einheit bei einer großen Familie von natürlichen Alkaloiden …