The striatal and pallidal complexes are basal ganglia structures that orchestrate learning
and execution of flexible behavior. Models of how the basal ganglia subserve these …

The prefrontal cortex (PFC) is considered to constitute the highest stage of neural integration
and to be devoted to representation and production of actions. Studies in primates have laid …

Compulsive behavior is a defining feature of disorders such as substance use disorders.
Current evidence suggests that corticostriatal circuits control the expression of established …

Background Activation of the mesolimbic dopamine system is positively reinforcing. After
repeated activation, some individuals develop compulsive reward-seeking behavior, which …

Background Alcohol use disorder (AUD) is a complex condition, and it remains unclear
which specific neuronal substrates mediate alcohol‐seeking and‐taking behaviors. Engram …

The Reln gene encodes for the extracellular glycoprotein Reelin, which regulates several
brain functions from development to adulthood, including neuronal migration, dendritic …

Uncontrolled drug-seeking and-taking behaviors are generally driven by maladaptive
corticostriatal synaptic plasticity. The orbital frontal cortex (OFC) and its projections to the …

A large body of research supports the notion that regions of the rodent frontal cortex regulate
reinstatement of cocaine seeking after cessation of intravenous cocaine self-administration …

Nitrogen narcosis is a neurological syndrome that manifests when humans or animals
encounter hyperbaric nitrogen, resulting in a range of motor, emotional, and cognitive …

Both clinical and animal studies showed that the impaired functions of the orbitofrontal
cortex (OFC) underlie the compulsive drug-seeking behavior of drug addiction. However, the …