Cancer is a disease of the genome caused by oncogene activation and tumor suppressor
gene inhibition. Deep sequencing studies including large consortia such as TCGA and …

Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …

Messanger RNA (mRNA) isoforms with alternative 3′‐untranslated regions (3′‐UTRs) are
produced by alternative polyadenylation (APA), which occurs during transcription in most …

A crucial feature of gene expression involves RNA processing to produce 3′ ends through
a process termed 3′ end cleavage and polyadenylation (CPA). This ensures the nascent …

Alternative polyadenylation (APA) is a molecular mechanism during a pre‐mRNA
processing that involves usage of more than one polyadenylation site (PA‐site) generating …

Alternative cleavage and polyadenylation within introns (intronic APA) generate shorter
mRNA isoforms; however, their physiological significance remains elusive. In this study, we …

Simple Summary MAGI1, 2, and 3 belong to a subgroup of the MAGUK family of scaffolding
proteins, and are comprised of 6 PDZ domains, 2 WW domains, and 1 GUK domain. MAGIs …

Cell migration is a highly conserved process involving cytoskeletal reorganization and
restructuring of the surrounding extracellular matrix. Although there are many studies …

The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …

Post-transcriptional regulation plays a key role in modulating gene expression, and the
perturbation of transcriptomic equilibrium has been shown to drive the development of …