Poor water solubility is one of the major challenges to the development of oral dosage forms
containing active pharmaceutical ingredients (APIs). Polymorphism in APIs leads to crystals …

Crystallization is an important and difficult to control unit operation in the pharmaceutical
industry. Crystallization can control molecular (ie, polymorphism) and particulate (ie, particle …

Over the last two decades, the use of template surfaces to induce heterogeneous crystal
nucleation has been explored primarily to address two different goals: first, as an alternative …

Solid-state guest exchange is used as an efficient method to prepare very metastable
polymorphs of indomethacin, including the polymorph observed earlier only in a mixture with …

Pyrazinamide is usually nucleated from solution as a dimeric form; it has rarely been
reported in the γ form (chain structure) crystallized from solution, especially from aqueous …

A novel class of crystalline hydrogen peroxide adducts, peroxosolvates of zwitterionic
sulfonic acids C2H7NO3S· H2O2 (1), p-C6H7NO3S· H2O2 (2), p-C6H7NO3S· 0.5 …

As a common type of pollutants in industrial wastewater, cationic dyes have attracted great
attentions. Using biodegradable N, N-di (carboxymethyl) glutamic acid (GLDA) as ligand …

The presence of different heterogeneous surfaces can directly influence the nucleation
kinetics, crystal growth, and morphology of active pharmaceutical ingredients (APIs) …

Excipients are crucial components of most pharmaceutical formulations. In the case of a
solid oral dosage formulation containing the salt form of a weakly ionizable drug, excipient …

A key challenge in rationally designing heterogeneous surfaces for controlling crystallization
is overcoming the lack of understanding the influence of surface properties has on …