In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …

Oncogenes can initiate tumors only in certain cellular contexts, which is referred to as
oncogenic competence. In melanoma, whether cells in the microenvironment can endow …

Melanoma exhibits numerous transcriptional cell states including neural crest-like cells as
well as pigmented melanocytic cells. How these different cell states relate to distinct …

INTRODUCTION Tumor analyses have shown that DNA mutations can transform cells in
some situations but not in others. In melanoma, BRAFV600E [serine/threonine-protein …

Base Editors are emerging as an innovative technology to introduce point mutations in
complex genomes. So far, the requirement of an NGG Protospacer Adjacent Motif (PAM) at a …

Cancer is a severe disease that substantially jeopardizes global health. Although
considerable efforts have been made to discover effective anti-cancer therapeutics, the …

There is a lack of appropriate melanoma models that can be used to evaluate the efficacy of
novel therapeutic modalities. Here, we discuss the current state of the art of melanoma …

Cancer has joined heart disease as the leading source of mortality in the US. In an era of
organoids, patient-derived xenografts, and organs on a chip, model organisms continue to …

Cancer cells exist in a complex ecosystem with numerous other cell types in the tumor
microenvironment (TME). The composition of this tumor/TME ecosystem will vary at each …